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proteín signálny adaptorový, Nod2

  1. Subject h.proteín signálny adaptorový, Nod2
    Subject h.Nod2 Signaling Adaptor Protein
    Entry termsproteín s nukleotidovou oligomerizačnou doménou 2
    English X referencesNucleotide Oligomerization Domain 2 Protein
    Scope note in EnglishA NOD signaling adaptor protein that contains two C-terminal leucine-rich domains which recognize bacterial PEPTIDOGLYCAN. It signals via an N-terminal capase recruitment domain that interacts with other CARD SIGNALING ADAPTOR PROTEINS such as RIP SERINE-THEONINE KINASES. The protein plays a role in the host defense response by signaling the activation of CASPASES and the MAP KINASE SIGNALING SYSTEM. Mutations of the gene encoding the nucleotide oligomerization domain 2 protein have been associated with increased susceptibility to CROHN DISEASE.
    Links (4) - ARTICLES
    (1) - CiBaMed
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