Number of the records: 1
CRISPR/Cas9
Record number d000076987 Date 06.06.2025 Type M Topical term CRISPR/Cas9 Other term Slovak (Pseudonym) proteín 9 asociovaný s CRISPR
Slovak (Pseudonym) Cas9 endonukleáza
Slovak (Pseudonym) Cas9 enzým
Slovak (Pseudonym) Cas9 proteín
See also (Later heading) CRISPR/Cas systémy
(Later heading) editovanie génov
(Skutočné meno) CRISPR/Cas systémy
(Skutočné meno) editovanie génov
UDC D08.811.277.352.355.325.150D12.776.097.219D12.776.212.500 Note An RNA-guided endodeoxyribonuclease that associates with CRISPR SEQUENCES in STREPTOCOCCUS PYOGENES and other bacteria where it participates in an adaptive immune function to cleave foreign DNA complimentary to small GUIDE RNA (sgRNAs). Structurally, Cas9 consists of an ALPHA-HELIX module and a nuclease module connected by a single helix. The nuclease module contains two enzymatic domains: RuvC, which cleaves non-target DNA strand, and an HNH nuclease domain, which cleaves the target strand. Specificity for the DNA target depends on the presence of a protospacer adjacent motif (PAM) sequence, a 2-6 nucleotide DNA sequence immediately following the sequence targeted by Cas9. 
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Number of the records: 1