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klozapín

  1. Record numberd003024
    Date06.06.2025
    TypeM
    Topical termklozapín
    See also(Skutočné meno) antagonisty serotonínu
    (Skutočné meno) antipsychotiká
    (Skutočné meno) antagonisty GABA
    UDCD03.633.300.240.220
    NoteA tricylic dibenzodiazepine, classified as an atypical antipsychotic agent. It binds several types of central nervous system receptors, and displays a unique pharmacological profile. Clozapine is a serotonin antagonist, with strong binding to 5-HT 2A/2C receptor subtype. It also displays strong affinity to several dopaminergic receptors, but shows only weak antagonism at the dopamine D2 receptor, a receptor commonly thought to modulate neuroleptic activity. Agranulocytosis is a major adverse effect associated with administration of this agent.
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