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izocitrátdehydrogenáza

  1. Record numberd007521
    Date06.06.2025
    TypeM
    Topical termizocitrátdehydrogenáza
    Other termEnglish (Pseudonym) NAD Isocitrate Dehydrogenase
    UDCD08.811.682.047.820.475
    NoteAn enzyme of the oxidoreductase class that catalyzes the conversion of isocitrate and NAD+ to yield 2-ketoglutarate, carbon dioxide, and NADH. It occurs in cell mitochondria. The enzyme requires Mg2+, Mn2+; it is activated by ADP, citrate, and Ca2+, and inhibited by NADH, NADPH, and ATP. The reaction is the key rate-limiting step of the citric acid (tricarboxylic) cycle. (From Dorland, 27th ed) (The NADP+ enzyme is EC 1.1.1.42.) EC 1.1.1.41.
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