Number of the records: 1  

myši knokautované

  1. Record numberd018345
    Date06.06.2025
    TypeM - MESH
    Topical termmyši knokautované
    Other termEnglish (Pseudonym) Knockout Mice
    Slovak (Pseudonym) myši knockout
    See also(Later heading) inžinierstvo genetické
    (Skutočné meno) techniky inaktivácie génu
    (Later heading) techniky inaktivácie génu
    UDCB01.050.050.136.500.500B01.050.150.900.649.313.992.635.505.500.550.455B01.050.150.900.649.313.992.635.505.500.800.500
    NoteStrains of mice in which certain GENES of their GENOMES have been disrupted, or knocked-out. To produce knockouts, using RECOMBINANT DNA technology, the normal DNA sequence of the gene being studied is altered to prevent synthesis of a normal gene product. Cloned cells in which this DNA alteration is successful are then injected into mouse EMBRYOS to produce chimeric mice. The chimeric mice are then bred to yield a strain in which all the cells of the mouse contain the disrupted gene. Knockout mice are used as EXPERIMENTAL ANIMAL MODELS for diseases (DISEASE MODELS, ANIMAL) and to clarify the functions of the genes.
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Number of the records: 1  

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