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neoplázia endokrinná mnohopočetná, typ 2b

  1. Record numberd018814
    Date06.06.2025
    TypeM
    Topical termneoplázia endokrinná mnohopočetná, typ 2b
    Other termEnglish (Pseudonym) MEN 2b
    English (Pseudonym) MEN 3
    English (Pseudonym) Neoplasia, Multiple Endocrine Type 2b
    English (Pseudonym) Neoplasms, Multiple Endocrine Type 2b
    Slovak (Pseudonym) nádory endokrinné mnohopočetné, typ 2b
    Slovak (Pseudonym) MEN2b
    Slovak (Pseudonym) MEN 2b
    Slovak (Pseudonym) MEN 3
    See also(Later heading) feochromocytóm
    (Later heading) karcinóm medulárny
    UDCC04.588.322.400.510C04.651.600.510C04.700.630.510C16.320.700.630.510C19.344.400.510
    NoteSimilar to MEN2A, it is also caused by mutations of the MEN2 gene, also known as the RET proto-oncogene. Its clinical symptoms include medullary carcinoma (CARCINOMA, MEDULLARY) of THYROID GLAND and PHEOCHROMOCYTOMA of ADRENAL MEDULLA (50%). Unlike MEN2a, MEN2b does not involve PARATHYROID NEOPLASMS. It can be distinguished from MEN2A by its neural abnormalities such as mucosal NEUROMAS on EYELIDS; LIP; and TONGUE, and ganglioneuromatosis of GASTROINTESTINAL TRACT leading to MEGACOLON. It is an autosomal dominant inherited disease.
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