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MAP kinázový signálny systém
Record number d020935 Date 06.06.2025 Type M - MESH Topical term MAP kinázový signálny systém Other term English (Pseudonym) MAP Kinase Cascade
English (Pseudonym) MAP Kinase Module
English (Pseudonym) MAP Kinase Signaling Cascade
English (Pseudonym) MAP Kinase Signaling Pathway
English (Pseudonym) MAP Kinase Signaling Pathways
Slovak (Pseudonym) ERK dráha
Slovak (Pseudonym) ERK signálna transdukčná dráha
Slovak (Pseudonym) ERK1 a ERK2 dráha
Slovak (Pseudonym) ERK1-2 dráha
Slovak (Pseudonym) JNK dráha
Slovak (Pseudonym) JNK signálna dráha
Slovak (Pseudonym) MAP kinázová kaskáda
Slovak (Pseudonym) MAP kinázový modul
Slovak (Pseudonym) MAP kinázové moduly
Slovak (Pseudonym) MAP kinázová signálna kaskáda
Slovak (Pseudonym) MAP kinázové signálne kaskády
Slovak (Pseudonym) MAP kinázová signálna dráha
Slovak (Pseudonym) MAP kinázové signálne dráhy
Slovak (Pseudonym) MEK-ERK dráha
Slovak (Pseudonym) kaskáda MAP-kinázy
Slovak (Pseudonym) p38 kinázová dráha
Slovak (Pseudonym) p38 kinázová signálna dráha
Slovak (Pseudonym) MAP kinázové signálne cesty
See also (Later heading) proteínkinázy aktivované mitogénmi
(Later heading) mitogénom aktivované proteínkinázy kinázy
(Later heading) MAP kináza kináza kinázy
(Skutočné meno) proteínkinázy aktivované mitogénmi
(Skutočné meno) mitogénom aktivované proteínkinázy kinázy
(Skutočné meno) MAP kináza kináza kinázy
UDC G02.111.820.560G03.493.560G04.835.560 Note An intracellular signaling system involving the mitogen-activated protein kinase cascades (three-membered protein kinase cascades). Various upstream activators, which act in response to extracellular stimuli, trigger the cascades by activating the first member of a cascade, MAP KINASE KINASE KINASES; (MAPKKKs). Activated MAPKKKs phosphorylate MITOGEN-ACTIVATED PROTEIN KINASE KINASES which in turn phosphorylate the MITOGEN-ACTIVATED PROTEIN KINASES; (MAPKs). The MAPKs then act on various downstream targets to affect gene expression. In mammals, there are several distinct MAP kinase pathways including the ERK (extracellular signal-regulated kinase) pathway, the SAPK/JNK (stress-activated protein kinase/c-jun kinase) pathway, and the p38 kinase pathway. There is some sharing of components among the pathways depending on which stimulus originates activation of the cascade. 
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