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skleróza amyotrofická laterálna

Subject h.	skleróza amyotrofická laterálna
Subject h.	Amyotrophic Lateral Sclerosis
Entry terms	ALS - amyotrofická laterálna skleróza skleróza amyotrofická laterálna, s demenciou skleróza amyotrofická laterálna, guamská forma ALS - guamský komplex parkinsonizmus - demencia skleróza amyotrofická laterálna, guamský komplex parkinsonizmu s demenciou choroba motorických neurónov, amyotrofická laterálna skleróza Lou Gehrigova choroba Gehrigova choroba choroba guamská Charcotova choroba demencia s amyotrofickou laterálnou sklerózou ALS, guamská forma
English X references	ALS - Amyotrophic Lateral Sclerosis Lou Gehrig Disease Motor Neuron Disease, Amyotrophic Lateral Sclerosis
Scope note in English	A degenerative disorder affecting upper MOTOR NEURONS in the brain and lower motor neurons in the brain stem and SPINAL CORD. Disease onset is usually after the age of 50 and the process is usually fatal within 3 to 6 years. Clinical manifestations include progressive weakness, atrophy, FASCICULATION, hyperreflexia, DYSARTHRIA, dysphagia, and eventual paralysis of respiratory function. Pathologic features include the replacement of motor neurons with fibrous ASTROCYTES and atrophy of anterior SPINAL NERVE ROOTS and corticospinal tracts. (From Adams et al., Principles of Neurology, 6th ed, pp1089-94)
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