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botulotoxíny

  1. Subject h.botulotoxíny
    Subject h.Botulinum Toxins
    Entry termsbotulín
    botulotoxíny klostrídiové
    neurotoxín Botulinum
    neurotoxíny botulínové
    toxíny Clostridium botulinum
    English X referencesBotulin
    Botulinum Neurotoxin
    Botulinum Neurotoxins
    Clostridium botulinum Toxins
    Scope note in EnglishToxic proteins produced from the species CLOSTRIDIUM BOTULINUM. The toxins are synthesized as a single peptide chain which is processed into a mature protein consisting of a heavy chain and light chain joined via a disulfide bond. The botulinum toxin light chain is a zinc-dependent protease which is released from the heavy chain upon ENDOCYTOSIS into PRESYNAPTIC NERVE ENDINGS. Once inside the cell the botulinum toxin light chain cleaves specific SNARE proteins which are essential for secretion of ACETYLCHOLINE by SYNAPTIC VESICLES. This inhibition of acetylcholine release results in muscular PARALYSIS.
    Pharmacology effect inhibítory uvoľňovania acetylcholínu
    neurotoxíny
    Pharmacology effect Acetylcholine Release Inhibitors
    Neurotoxins
    See also reference (FX) in Slovak botulizmus
    See also reference (FX) in English Botulism
    Links (69) - ARTICLES
    (3) - MeSH descriptor
    (3) - CiBaMed
    (9) - BOOKS
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Number of the records: 1  

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