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systém enzýmov cytochrómu P-450

Subject h.	systém enzýmov cytochrómu P-450
Subject h.	Cytochrome P-450 Enzyme System
Entry terms	rodina CYP450 superrodina CYP450 systém cytochrómu P-450, enzýmový CYP450 rodina enzýmov cytochróm P-450 enzým cytochróm P450 enzýmy cytochróm P450 rodiny cytochrómov P450 cytochróm P 450 monooxygenáza cytochróm P450 oxygenáza monooxygenázy závislé od cytochrómu P-450 superrodina cytochrómov P450 P450 enzým P-450 enzýmy
English X references	Cytochrome P-450 Cytochrome P-450 Enzyme Cytochrome P-450-Dependent Monooxygenase P-450 Enzyme P450 Enzyme
Scope note in English	A superfamily of hundreds of closely related HEMEPROTEINS found throughout the phylogenetic spectrum, from animals, plants, fungi, to bacteria. They include numerous complex monooxygenases (MIXED FUNCTION OXYGENASES). In animals, these P-450 enzymes serve two major functions: (1) biosynthesis of steroids, fatty acids, and bile acids; (2) metabolism of endogenous and a wide variety of exogenous substrates, such as toxins and drugs (BIOTRANSFORMATION). They are classified, according to their sequence similarities rather than functions, into CYP gene families (>40% homology) and subfamilies (>59% homology). For example, enzymes from the CYP1, CYP2, and CYP3 gene families are responsible for most drug metabolism.
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