MEFV proteín marenostrín proteín stredomorskej horúčky proteín asociovaný so stredomorskou horúčkou proteín spojený so stredomorskou horúčkou TRIM20 proteín
Scope note in English
A tripartite motif protein that consists of an N-terminal pyrin domain, a central coiled-coil region and B-box type ZINC FINGER, and C-terminal regions that mediate homotrimerization and interactions with other proteins (the B30.2/SPRY DOMAIN). It is expressed primarily by mature GRANULOCYTES and associates with the cytoskeleton in the perinuclear area as well as AUTOPHAGOSOMES, where it co-ordinates the assembly of AUTOPHAGY-RELATED PROTEINS and degradation of INFLAMMASOME components. It functions in INNATE IMMUNITY and INFLAMMATION; mutations in the Pyrin protein (MEFV) gene are associated with FAMILIAL MEDITERRANEAN FEVER.
See also reference (FX) in Slovak
doména pyrínová
See also reference (FX) in English
Pyrin Domain
Links
(2) - ARTICLES
(1) - MeSH descriptor
subject heading
openseadragon
Number of the records: 1
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