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kináza anaplastického lymfómu
Record number d000077548 Date 06.06.2025 Type M - MESH Topical term kináza anaplastického lymfómu Other term Slovak (Pseudonym) ALK kináza
Slovak (Pseudonym) ALK tyrozínkinázový receptor
Slovak (Pseudonym) tyrozínkináza anaplastického lymfómu, receptorová
Slovak (Pseudonym) CD246 antigén
Slovak (Pseudonym) NPM-ALK
Slovak (Pseudonym) nukleofozmín – kináza anaplastického lymfómu
Slovak (Pseudonym) nukleofosmín – kináza anaplastického lymfómu
UDC D08.811.913.696.620.682.725.400.002D12.776.476.568.400.002D12.776.543.750.630.002 Note A receptor tyrosine kinase that is essential for development and differentiation of the nervous system in response to secreted growth factors. It phosphorylates the first tyrosine of the Y-x-x-x-Y-Y motif of targets that include PROTO-ONCOGENE PROTEINS C-CBL; INSULIN RECEPTOR SUBSTRATE-1; and MITOGEN-ACTIVATED PROTEIN KINASES, leading to activation of the MAPK signaling pathway and cell proliferation. A chromosomal aberration involving the ALK gene results in its constitutive expression in some cases of NON-HODGKIN LYMPHOMA. 
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Number of the records: 1