Number of the records: 1  

zidovudín

  1. Record numberd015215
    Date06.06.2025
    TypeM - MESH
    Topical termzidovudín
    Other termEnglish (Pseudonym) Azidothymidine
    English (Pseudonym) AZT (Antiviral)
    Slovak (Pseudonym) azidotymidín
    Slovak (Pseudonym) AZT (antivírusový)
    See also(Skutočné meno) antimetabolity
    (Skutočné meno) inhibítory reverznej transkriptázy
    (Skutočné meno) látky proti HIV
    UDCD03.383.742.680.705.950D13.570.230.500.950D13.570.230.855.950D13.570.685.705.950
    NoteA dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by an azido group. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. The compound is a potent inhibitor of HIV replication, acting as a chain-terminator of viral DNA during reverse transcription. It improves immunologic function, partially reverses the HIV-induced neurological dysfunction, and improves certain other clinical abnormalities associated with AIDS. Its principal toxic effect is dose-dependent suppression of bone marrow, resulting in anemia and leukopenia.
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