látky antineoplastické alkylačné látky protinádorové alkylačné
Angl. X odkazy
Alkylating Agents, Antineoplastic
Vysvetľujúca pozn. v angl.
A class of drugs that differs from other alkylating agents used clinically in that they are monofunctional and thus unable to cross-link cellular macromolecules. Among their common properties are a requirement for metabolic activation to intermediates with antitumor efficacy and the presence in their chemical structures of N-methyl groups, that after metabolism, can covalently modify cellular DNA. The precise mechanisms by which each of these drugs acts to kill tumor cells are not completely understood. (From AMA, Drug Evaluations Annual, 1994, p2026)
Odkazy
(12) - ČLÁNKY
(31) - heslo MeSH
(1) - CiBaMed
(1) - KNIHY
predmetové heslo
openseadragon
Počet záznamov: 1
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