Počet záznamov: 1
progranulíny
Č. záznamu d000077153 Dátum 06.06.2025 Typ M - MESH Tematický termín progranulíny Iný termín Slovenčina (Pseudonym) akrogranín
Slovenčina (Pseudonym) Acrogranin
Slovenčina (Pseudonym) prekurzor granulínu
Slovenčina (Pseudonym) proteín prekurzorový granulínový
Slovenčina (Pseudonym) faktor rastový, odvodený od PC buniek
Slovenčina (Pseudonym) proepitelín
Slovenčina (Pseudonym) progranulín
MDT D06.472.699.682D12.644.276.917D12.776.467.917D12.776.811.703D23.529.917 Poznámka Cysteine-rich, precursor glycoproteins encoded by the granulin gene (GRN). They contain granulin-repeats separated by linker sequences that are cleaved by a variety of proteases to release the individual GRANULIN PEPTIDES. The mammalian progranulin is composed of a half-granulin repeat followed by 7 granulin repeats. The mammalian GRANULINS are named PARAGRANULIN and granulin 1-7 for their order in the progranulin propeptide. Progranulin has growth-factor like effects and is expressed over a broad range of tissues. Under-expression of progranulin is linked to neurodegenerative diseases including FRONTOTEMPORAL DEMENTIA and NEURONAL CEROID LIPOFUSCINOSIS, while over-expression is linked to metabolic diseases including OBESITY, and INSULIN RESISTANCE. 
predmetové heslo
Počet záznamov: 1