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klozapín
Č. záznamu d003024 Dátum 06.06.2025 Typ M Tematický termín klozapín Pozri tiež (Skutočné meno) antagonisty serotonínu
(Skutočné meno) antipsychotiká
(Skutočné meno) antagonisty GABA
MDT D03.633.300.240.220 Poznámka A tricylic dibenzodiazepine, classified as an atypical antipsychotic agent. It binds several types of central nervous system receptors, and displays a unique pharmacological profile. Clozapine is a serotonin antagonist, with strong binding to 5-HT 2A/2C receptor subtype. It also displays strong affinity to several dopaminergic receptors, but shows only weak antagonism at the dopamine D2 receptor, a receptor commonly thought to modulate neuroleptic activity. Agranulocytosis is a major adverse effect associated with administration of this agent. 
predmetové heslo
Počet záznamov: 1