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systém enzýmov cytochrómu P-450

  1. Heslosystém enzýmov cytochrómu P-450
    Heslo anglickyCytochrome P-450 Enzyme System
    Odkazyrodina CYP450
    superrodina CYP450
    systém cytochrómu P-450, enzýmový
    CYP450 rodina enzýmov
    cytochróm P-450
    enzým cytochróm P450
    enzýmy cytochróm P450
    rodiny cytochrómov P450
    cytochróm P 450 monooxygenáza
    cytochróm P450 oxygenáza
    monooxygenázy závislé od cytochrómu P-450
    superrodina cytochrómov P450
    P450 enzým
    P-450 enzýmy
    Angl. X odkazyCytochrome P-450
    Cytochrome P-450 Enzyme
    Cytochrome P-450-Dependent Monooxygenase
    P-450 Enzyme
    P450 Enzyme
    Vysvetľujúca pozn. v angl.A superfamily of hundreds of closely related HEMEPROTEINS found throughout the phylogenetic spectrum, from animals, plants, fungi, to bacteria. They include numerous complex monooxygenases (MIXED FUNCTION OXYGENASES). In animals, these P-450 enzymes serve two major functions: (1) biosynthesis of steroids, fatty acids, and bile acids; (2) metabolism of endogenous and a wide variety of exogenous substrates, such as toxins and drugs (BIOTRANSFORMATION). They are classified, according to their sequence similarities rather than functions, into CYP gene families (>40% homology) and subfamilies (>59% homology). For example, enzymes from the CYP1, CYP2, and CYP3 gene families are responsible for most drug metabolism.
    Odkazy (59) - ČLÁNKY
    (2) - CiBaMed
    (20) - KNIHY
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