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klbká neurofibrilárne
SYS d016874 LBL 00000cz--a2200000n--4500 005 20250606213934.5 008 920502|||anznnbabn-----------|-a|a------ 040 $b slo $a DNLM $d BA006 $d BA006 $d BA006 065 $a A08.675.609.520 065 $a A11.284.430.214.190.750.640.520 065 $a A11.671.573.520 066 $a 01 $c 03 150 $a klbká neurofibrilárne $x CH $x CL $x DE $x EN $x GE $x IM $x ME $x MI $x PA $x PH $x PS $x RE $x TR $x UL $x VI $2 slo 450 $w v $a splete neurofibrilárne $2 slo 550 $7 sllk_us_auth*d009454 $Y Neurofibrils $w b $a neurofibrily 550 $7 sllk_us_auth*d009454 $Y Neurofibrils $w p $a neurofibrily 550 $7 sllk_us_auth*d016900 $Y Neurofilament Proteins $w p $a proteíny neurofilamentové 550 $7 sllk_us_auth*d024801 $Y Tauopathies $w p $a tauopatie 550 $7 sllk_us_auth*d055956 $Y Diffuse Neurofibrillary Tangles with Calcification $w p $a klbká neurofibrilárne difúzne, s kalcifikáciou 550 $7 sllk_us_auth*d024801 $Y Tauopathies $w b $a tauopatie 550 $7 sllk_us_auth*d055956 $Y Diffuse Neurofibrillary Tangles with Calcification $w b $a klbká neurofibrilárne difúzne, s kalcifikáciou 665 $a 92 $2 eng 665 $a Neurofibrils (1968-1991) $2 eng 680 9-
$i Abnormal structures located in various parts of the brain and composed of dense arrays of paired helical filaments (neurofilaments and microtubules). These double helical stacks of transverse subunits are twisted into left-handed ribbon-like filaments that likely incorporate the following proteins: (1) the intermediate filaments: medium- and high-molecular-weight neurofilaments; (2) the microtubule-associated proteins map-2 and tau; (3) actin; and (4) UBIQUITINS. As one of the hallmarks of ALZHEIMER DISEASE, the neurofibrillary tangles eventually occupy the whole of the cytoplasm in certain classes of cell in the neocortex, hippocampus, brain stem, and diencephalon. The number of these tangles, as seen in post mortem histology, correlates with the degree of dementia during life. Some studies suggest that tangle antigens leak into the systemic circulation both in the course of normal aging and in cases of Alzheimer disease. $2 eng 750 -2
$a Neurofibrillary Tangles $2 eng 980 $x M
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