0012880 2020 RIV GB eng J
Grebeňová, Dana - Holoubek, Aleš - Röselová, Pavla - Obr, Adam - Brodská, Barbora - Kuželová, Kateřina^G
PAK1, PAK1delta15, and PAK2: similarities, differences and mutual interactions.
Scientific reports. Vol. 9, no. [November] (2019), art. no. 17171. ISSN 2045-2322
Grant: Grantová agentura ČR GA16-16169S; Ministerstvo zdravotnictví IP
Klíčová slova: PAK1 * PAK1delta15 * PAK2
Cite Score: 7.200, rok: 2019; SJR: 1.341, rok: 2019; IF: 3.998, rok: 2019
DOI: 10.1038/s41598-019-53665-6

Anotace: P21-activated kinases (PAK) are key effectors of the small GTPases Rac1 and Cdc42, as well as of Src family kinases. In particular, PAK1 has several well-documented roles, both kinase-dependent and kinase-independent, in cancer-related processes, such as cell proliferation, adhesion, and migration.