0013287 2023 RIV US eng J
Kořánová, Tereza - Dvořáček, Lukáš - Grebeňová, Dana - Röselová, Pavla - Obr, Adam - Kuželová, Kateřina^G
PAK1 and PAK2 in cell metabolism regulation.
Journal of cellular biochemistry. Vol. 123, no. 2 (2022), s. 375-389. ISSN 0730-2312
Institucionální podpora: RVO:00023736
Klíčová slova: cell metabolism * glycolysis * oxidative phosphorylation * p21-activated kinase 1 * p21-activated kinase 2
Cite Score: 11.800, rok: 2022; SJR: 0.779, rok: 2022; IF: 4, rok: 2022
DOI: 10.1002/jcb.30175

Anotace: We analyzed the impact of PAK inhibition by small molecule inhibitors, small interfering RNA, or gene knockout on the rates of mitochondrial respiration and aerobic glycolysis. Pharmacological inhibition of PAK group I by IPA-3 induced a strong decrease in metabolic rates in human adherent cancer cell lines, leukemia/lymphoma cell lines, and primary leukemia cells. The immediate effect of FRAX597, which inhibits PAK kinase activity, was moderate, indicating that PAK nonkinase functions are essential for cell metabolism.