0013291 2023 RIV DE eng J
Malý, M. - Riedel, Tomáš - Štikarová, Jana^G - Suttnar, Jiří - Kotlín, Roman - Hajšl, M. - Toušek, P. - Kaufmanová, Jiřina - Kučerka, O. - Weisel, J.W. - Dyr, Jan Evangelista
Incorporation of fibrin, platelets, and red blood cells into a coronary thrombus in time and space.
Thrombosis and haemostasis. Vol. 122, no. 3 (2022), s. 434-444. ISSN 0340-6245
Grant: Ministerstvo zdravotnictví NV18-08-00149; Grantová agentura ČR GBP205/12/G118; Grantová agentura ČR GA19-02739S
Institucionální podpora: RVO:00023736
Klíčová slova: coronary * aspiration thrombectomy * scanning electron microskopy
Cite Score: 10.500, rok: 2022; SJR: 1.565, rok: 2022; IF: 6.7, rok: 2022
DOI: 10.1055/s-0041-1739193

Anotace: We describe the internal structure, spatial organization and dynamic formation of coronary artery thrombi from ST-segment elevation myocardial infarction patients. Scanning electron microscopy (SEM) revealed significant differences among four groups of patients (less than2 hours, 2-6 hours, 6-12 hours, and more than12 hours) related to the time of ischemia. Coronary artery thrombi from patients presenting less than 2 hours after the infarction were almost entirely composed of platelets, with small amounts of fibrin and red blood cells. In contrast, thrombi from late presenters (more than 12 hours) consisted of mainly platelets at the distal end, where clotting was initiated, with almost no platelets at the proximal end, while the red blood cell content went from low at the initiating end to more than 90pct at the proximal end.