0013297 2022 RIV CZ eng J
Smetana, Karel^G - Klamová, Hana - Mikulenková, Dana - Čermák, Jaroslav - Otevřelová, Petra - Karban, J. - Trněný, M.
The cell body space occupied by the nucleus during the cell differentiation in human lymphocytic, granulocytic and erythroid cell lineages.
Physiological research. Roč. 70, č. 5 (2021), s. 701-707. ISSN 0862-8408
Institucionální podpora: RVO:00023736
Klíčová slova: nucleus * cell space * cell differentiation
Cite Score: 3.200, rok: 2021; SJR: 0.528, rok: 2021; IF: 2.139, rok: 2021
DOI: 10.33549/physiolres.934691

Anotace: The present nuclear and cell body diameter measurements demonstrated size differences of the approximate cell space estimate occupied by the cell nucleus during the cell differentiation in lymphocytic, granulocytic and erythroid cell lineages. These lineages were used as convenient models because all differentiation steps were easily identified and accessible in diagnostic peripheral blood or bone marrow smears of blood donors (BDs), patients suffering from chronic lymphocytic leukemia (CLL), patients with chronic myeloid leukemia (CML) and refractory anemia (RA) of the myelodysplastic syndrome (MDS). The cell space occupied by the nucleus was constant and did not change during the cell differentiation in the lymphocytic cell lineages of BDs and CLL patients despite the decreased cell size. In contrary, the cell space occupied by the nucleus markedly decreased in differentiating cells of granulocytic and erythroid lineages of patients suffering from CML. In the erythroid cell lineage in patients with RA of MDS the small reduction of the cell space occupied by the nucleus during the differentiation was not significant.