Počet záznamů: 1
Specific immune response to mRNA vaccines against COVID-19 in patients receiving allogeneic stem cell transplantation for myeloid malignancy was altered by immunosuppressive therapy
- 1.0013538 2024 RIV GB eng J
Macková, Jana - Hainz, Petr - Kryštofová, Jitka - Roubalová, Kateřina - Šťastná Marková, Markéta - Vaníková, Šárka - Musil, Jan - Vydra, Jan - Němečková, ŠárkaG
Specific immune response to mRNA vaccines against COVID-19 in patients receiving allogeneic stem cell transplantation for myeloid malignancy was altered by immunosuppressive therapy.
Leukemia research. Vol. 130, no. July (2023), art. no. 107314. ISSN 0145-2126
Grant: Ministerstvo zdravotnictví NU22-E-138
Institucionální podpora: RVO:00023736
Klíčová slova: immune response * covid-19 * allogeneic stem cell transplantation * covid-19
Cite Score: 4.300, rok: 2022; SJR: 0.673, rok: 2022; IF: 2.700, rok: 2022
DOI: 10.1016/j.leukres.2023.107314
Anotace: Allogeneic hematopoietic stem cell transplant (allo-HSCT) recipients are at high risk of complications associated with COVID-19 infection due to dysfunction of their immune system. Vaccination can protect from the adverse consequences of COVID-19. However, studies on the efficacy of COVID-19 vaccines in HSCT recipients with insufficient post-HSCT immune reconstitution are still scarce. In our study, we determined how immunosuppressive medication and the reconstitution of the cellular immune system influenced T cell responses specific for the surface glycoprotein of SARS-CoV-2 virus (S antigen) after two doses of mRNA vaccine against COVID-19 in patients with myeloid malignancies treated with HSCT.
Počet záznamů: 1