0013572 2024 RIV CZ eng J
Smetana, Karel^G - Mikulenková, Dana - Klamová, Hana - et al.
Technical note cell dysplasia: cell dysplastic features (a morphological note).
Folia biologica. Roč. 69, č. 1 (2023) s. 34-39. ISSN 0015-5500
Institucionální podpora: RVO:00023736
Klíčová slova: acute myeloblastic leukaemia * myelodysplastic syndrome * chronic lymphocytic leukemia
Cite Score: 1.400, rok: 2023; SJR: 0.265, rok: 2023; IF: 1.1, rok: 2023
DOI: 10.14712/fb2023069010034

Anotace: Cell dysplasia is a currently used term describing various cellular developmental abnormalities visible by microscopy. However, detailed description of these developmental abnormalities might provide useful information not only on the cell state but also on the abnormal developmental steps of cell lineages, tissues and organs. The frequently noted visualized cell dysplastic features reflect nuclear- or nucleolar-cytoplasmic anarchy (asynchrony), premature heterochromatin condensation state, marked aneuploidy, abnormal nucleus-cytoplasm ratio, abnormality of cell organelles including mitochondria, abnormal presence or absence of cell lineage-specific granules, and formation of peripheral buds or blebbing on the cell surface. The description of these frequently occurring cell dysplastic features might also be helpful in recognizing and studying defined specific disorders of the “whole macro-body” expressed as a disease.