0013588 2025 RIV FR eng J
Cerovská, Ela - Šálek, Cyril - Kundrát, David - Šestáková, Šárka - Pešek, Adam - Brožinová, Ivana - Beličková, Monika - Remešová, Hana^G
ABC transporters are predictors of treatment failure in acute myeloid leukaemia.
Biomedicine and pharmacotherapy. Vol. 170, no. January (2024), art. no. 115930. ISSN 0753-3322
Institucionální podpora: RVO:00023736
Klíčová slova: ABC transporter * AML * anthracycline
Cite Score: 12.800, rok: 2024; SJR: 1.775, rok: 2024; IF: 7.5, rok: 2024
DOI: 10.1016/j.biopha.2023.115930

Anotace: To date, no chemoresistance predictors are included in acute myeloid leukaemia (AML) prognostic scoring systems to distinguish responding and refractory AML patients prior to chemotherapy. ABC transporters have been described as altering AML chemosensitivity. However, a relevant study investigating their role at various molecular levels was lacking. ABC transporters, especially ABCC1 seem to contribute substantially to AML chemoresistance. A detailed understanding of chemoresistance mechanisms and the clinical implications of chemosensitivity predictors may lead to alternative therapeutic approaches for AML patients with unveiled chemoresistance signatures.