Počet záznamů: 1
Attenuated cell cycle and DNA damage response transcriptome signatures and overrepresented cell adhesion processes imply accelerated progression in patients with lower‐risk myelodysplastic neoplasms
- 1.0013596 2025 RIV US eng J
Kaisrlíková, Monika - Kundrát, David - Kořalková, P. - Trsová, Iva - Lenertová, Zuzana - Votavová, Hana - Dostálová Merkerová, Michaela - Krejčík, Zdeněk - Veselá, Jitka - Vostrý, Martin - Šimečková, Radka - Šťastná Marková, Markéta - Lauermannová, Marie - Jonášová, A. - Čermák, Jaroslav - Divoký, V. - Beličková, MonikaG
Attenuated cell cycle and DNA damage response transcriptome signatures and overrepresented cell adhesion processes imply accelerated progression in patients with lower‐risk myelodysplastic neoplasms.
International journal of cancer. Vol. 154, no. 9 (2024), s. 1652-1668. ISSN 0020-7136
Grant: Ministerstvo zdravotnictví NU21-03-00565; Ministerstvo školství, mládeže a tělovýchovy LM2023033
Institucionální podpora: RVO:00023736
Klíčová slova: MDS * cell cycle * DNA damage
Cite Score: 12.600, rok: 2024; SJR: 2.251, rok: 2024; IF: 4.7, rok: 2024
DOI: 10.1002/ijc.34834
Anotace: Patients with myelodysplastic neoplasms (MDS) are classified according to the risk of acute myeloid leukemia transformation. Some lower-risk MDS patients (LR-MDS) progress rapidly despite expected good prognosis. Using diagnostic samples, we aimed to uncover the mechanisms of this accelerated progression at the transcriptome level. DNA damage response (DDR) and energy metabolism-related pathways were downregulated in prMDS samples, whereas cell adhesion processes were upregulated. Also, prMDS samples showed high levels of aberrant splicing and global lncRNA expression that may contribute to the attenuation of DDR pathways. The attenuation of DDR-related gene-expression signature may refine risk assessment in LR-MDS patients.
Počet záznamů: 1