Počet záznamů: 1
Absence of pre-transplant T cell response against LAA is associated with Flt3-ITD mutation and increased relapse-risk in AML patients with HSCT
- 1.0013783 2026 RIV GB eng J
Šťastná Marková, Markéta - Hainz, Petr - Kryštofová, Jitka - Macková, Jana - Roubalová, Kateřina - Vydra, Jan - Němečková, ŠárkaG
Absence of pre-transplant T cell response against LAA is associated with Flt3-ITD mutation and increased relapse-risk in AML patients with HSCT.
Immunotherapy. Vol. 17, no. 3 (2025), s. 185-190. ISSN 1750-743X
Institucionální podpora: RVO:00023736
Klíčová slova: ELISPOT-interferon gamma * FLT3/ITD * hematopoietic stem cell transplantation
Cite Score: 4.900, rok: 2024; SJR: 0.825, rok: 2024; IF: 2.3, rok: 2024
DOI: 10.1080/1750743X.2025.2478804
Anotace: This study aimed to examine changes in the repertoire of functional T-cells specific for six leukemia-associated antigens (LAA), including WT1, PRAME, MUC1, CCNA1, NPM1, and NPM1c, during immune reconstitution following allogeneic transplantation of hematopoietic stem cells (HSCT) in patients with acute myeloid leukemia. Our results showed that the T-cell response to LAA can be reconstituted after HSCT. Measurement of functional pre-transplant T-cell responses against multiple LAAs could help to find patients with an increased risk of relapse.
Počet záznamů: 1