Associations between recurrent mutations and blast immunophenotype in acute myeloid leukemia

0013247 2022 RIV US eng J
Kuželová, Kateřina - Brodská, Barbora - Marková, Jana - Petráčková, Martina - Ransdorfová, Šárka - Gašová, Zdenka - Šálek, Cyril
Associations between recurrent mutations and blast immunophenotype in acute myeloid leukemia.
The bioRxiv preprint server. [April] (2021), art. no. 439800
Institucionální podpora: RVO:00023736
Klíčová slova: AML * immunophenotype * NPM1 mutation * flow cytometry * FLT3/ITD * DNMT3A mutations * Tim-3
DOI: 10.1101/2021.04.14.439800

Anotace: The immune system undoubtly plays an important role in final elimination of residual leukemic cells during acute myeloid leukemia (AML) therapy. However, the anti-leukemia immune response can be inhibited by a variety of mechanisms enabling immune escape and eventual disease relapse. We analyzed selected markers of immune escape on AML cells at diagnosis (N = 53) and used them for hierarchical clustering analysis, which yielded distinct clusters with different incidence of mutations in nucleophosmin 1 (NPM1) and in the methyltransferase DNMT3A.