0013619 2025 RIV GB eng J
Šestáková, Šárka - Šálek, Cyril - Kundrát, David - Cerovská, Ela - Vydra, Jan - Ježíšková, I. - Folta, A. - Mayer, J. - Cetkovský, Petr - Remešová, Hana^G
MethScore as a new comprehensive DNA methylation-based value refining the prognosis in acute myeloid leukemia.
Clinical epigenetics. Vol. 16, no. 1 (2024), art. no. 17. ISSN 1868-7075
Institucionální podpora: RVO:00023736
Klíčová slova: AML * DNA methylation * NGS
Cite Score: 8.800, rok: 2024; SJR: 1.833, rok: 2024; IF: 4.4, rok: 2024
DOI: 10.1186/s13148-024-01625-x

Anotace: Changes in DNA methylation are common events in the pathogenesis of acute myeloid leukemia (AML) and have been repeatedly reported as associated with prognosis. However, studies integrating these numerous and potentially prognostically relevant DNA methylation changes are lacking. Therefore, we aimed for an overall evaluation of these epigenetic aberrations to provide a comprehensive NGS-based approach of DNA methylation assessment for AML prognostication