0013665 2025 RIV US eng J
Ostheim, P. - Tichý, A. - Badie, C. - Davídková, M. - Kultová, G. - Marková Šťastná, Markéta - et al.
Applicability of gene expression in saliva as an alternative to blood for biodosimetry and prediction of radiation-inducede health effects.
Radiation research. Vol. 201, no. 5 (2024), s. 523-534. ISSN 0033-7587
Institucionální podpora: RVO:00023736
Klíčová slova: radiation * radiation response * saliva
Cite Score: 4.300, rok: 2024; SJR: 0.653, rok: 2024; IF: 2.7, rok: 2024
DOI: 10.1667/RADE-23-00176.1

Anotace: As the great majority of gene expression (GE) biodosimetry studies have been performed using blood as the preferred source of tissue, searching for simple and less-invasive sampling methods is important when considering biodosimetry approaches. Knowing that whole saliva contains an ultrafiltrate of blood and white blood cells, it is expected that the findings in blood can also be found in saliva. This human in vivo study aims to examine radiation-induced GE changes in saliva for biodosimetry purposes and to predict radiation-induced disease, which is yet poorly characterized. Furthermore, we examined whether transcriptional biomarkers in blood can also be found equivalently in saliva.