Early immune response in mice immunized with a semi-split inactivated vaccine against SARS-CoV-2 containing S protein-free particles and subunit S protein

0013150 2021 US eng J
Petráš, M. - Lesný, Petr - Musil, Jan - Limberková, R. - Pátíková, A. - Jirsa, M. - Krsek, D. - Březovský, P. - Koladiya, Abhishek - Vaníková, Šárka - Macková, B. - Jírová, D. - Krijt, Matyáš - et al.
Early immune response in mice immunized with a semi-split inactivated vaccine against SARS-CoV-2 containing S protein-free particles and subunit S protein.
The bioRxiv preprint server. [November] (2020), art. no. 366641
Institucionální podpora: RVO:00023736
Klíčová slova: SARS-CoV-2 * immune response * vaccine
DOI: 10.1101/2020.11.03.366641

Anotace: The development of a vaccine against COVID-19 is a hot topic for many research laboratories all over the world. Our aim was to design a semi-split inactivated vaccine offering a wide range of multi-epitope determinants important for the immune system including not only the spike (S) protein but also the envelope, membrane and nucleocapsid proteins.