Phenotype and oxidative burst of low-density neutrophil subpopulations are altered in common variable immunodeficiency patients

0013584 2025 RIV US eng J
Slanina, P. - Štíchová, J. - Bosáková, V. - Staniczková Zambo, I. - Hortová Kohoutková, M. - Lázničková, P. - Chovancová, Z. - Litzman, J. - Plucarová, T. - Frič, Jan - Vlková, M.
Phenotype and oxidative burst of low-density neutrophil subpopulations are altered in common variable immunodeficiency patients.
Cytometry part B: clinical cytometry. Vol. 106, no. 2 (2024), s. 99-112. ISSN 0196-4763
Institucionální podpora: RVO:00023736
Klíčová slova: common variable immunodeficiency * intravenous immunoglobulins * low-density neutrophils
DOI: 10.1002/cyto22150

Anotace: Common variable immunodeficiency disorder (CVID) is the most common form of primary antibody immunodeficiency. Due to low antibody levels, CVID patients receive intravenous or subcutaneous immunoglobulin replacement therapy as treatment. CVID is associated with the chronic activation of granulocytes, including an increased percentage of low-density neutrophils (LDNs). In this study, we examined changes in the percentage of LDNs and the expression of their surface markers in 25 patients with CVID and 27 healthy donors (HD) after in vitro stimulation of whole blood using IVIg. An oxidative burst assay was used to assess the functionality of LDNs.