Hepcidin and ferritin levels as markers of immune cell activation during septic shock, severe COVID-19 and sterile inflammation

0013512 2024 RIV CH eng J
Hortová Kohoutková, M. - Skotáková, M. - Onyango, I.G. - Slezáková, M. - Panovský, R. - Opatřil, L. - Slanina, P. - De Zuani, M. - Mrkva, O. - Andrejčinová, I. - Lázničková, P. - Dvončová, M. - Mýtniková, A. - Ostland, V. - Šitina, M. - Stokin, G.B. - Šrámek, V. - Vlková, M. - Helán, M. - Frič, Jan^G
Hepcidin and ferritin levels as markers of immune cell activation during septic shock, severe COVID-19 and sterile inflammation.
Frontiers in immunology. Vol. 14, no. January (2023), art. no. 1110540. ISSN 1664-3224
Institucionální podpora: RVO:00023736
Klíčová slova: COVID‐19 * ferritin * hepcidin
Cite Score: 9.400, rok: 2022; SJR: 2.022, rok: 2022; IF: 7.300, rok: 2022
DOI: 10.3389/fimmu.2023.1110540

Anotace: Major clinically relevant inflammatory events such as septic shock and severe COVID-19 trigger dynamic changes in the host immune system, presenting promising candidates for new biomarkers to improve precision diagnostics and patient stratification. Hepcidin, a master regulator of iron metabolism, has been intensively studied in many pathologies associated with immune system activation, however these data have never been compared to other clinical settings. Thus, we aimed to reveal the dynamics of iron regulation in various clinical settings and to determine the suitability of hepcidin and/or ferritin levels as biomarkers of inflammatory disease severity.