0011769 2018 RIV DK eng J
Válka, Jan - Veselá, Jitka - Votavová, Hana - Dostálová-Merkerová, Michaela - Horáková, Zuzana - Campr, V. - Březinová, Jana - Čermák, Jaroslav - Beličková, Monika - Zemanová, Z. - Jonášová, A.
Differential expression of homologous recombination DNA repair genes in the early and advanced stages of myelodysplastic syndrome.
European journal of haematology. Vol. 99, no. 4 (2017), s. 323-331. ISSN 0902-4441
Grant: Ministerstvo zdravotnictví NV16-33485A; Ministerstvo zdravotnictví NV16-31689A; Ministerstvo zdravotnictví IP
Klíčová slova: RAD51 * DNA repair * homologous recombination * MDS
Cite Score: 4.600, rok: 2017; SJR: 1.060, rok: 2017; IF: 2.595, rok: 2017
DOI: 10.1111/ejh.12920

Anotace: The high incidence of mutations and cytogenetic abnormalities in patients with myelodysplastic syndrome (MDS) suggests that defects in DNA repair mechanisms. We monitored DNA repair pathways in MDS and their alterations during disease progression. Expression profiling of DNA repair genes was performed on CD34+ cells and paired samples were used for monitoring of RAD51 and XRCC2 gene expression during disease progression. Immunohistochemical staining for RAD51 was done on histology samples. Our study demonstrates that the expression of DNA repair factors, primarily RAD51 and XRCC2, is deregulated in MDS patients and presents a specific pattern with respect to prognostic categories.