0011770 2019 RIV US eng J
Röselová, Pavla - Obr, Adam - Holoubek, Aleš - Grebeňová, Dana - Kuželová, Kateřina^G
Adhesion structures in leukemia cells and their regulation by Src family kinases.
Cell adhesion & migration. Vol. 12, č. 3 (2018), s. 286-298. ISSN 1933-6918
Grant: Ministerstvo zdravotnictví IP; Grantová agentura ČR GA16-16169S
Klíčová slova: leukemia cells * adhesion * fibronectin * Src family kinases (SFK)
Cite Score: 6.400, rok: 2018; SJR: 1.605, rok: 2018; IF: 3.296, rok: 2018
DOI: 10.1080/19336918.2017.1344796

Anotace: Interaction of leukemia blasts with the bone marrow extracellular matrix often results in protection of leukemia cells from chemotherapy and in persistence of the residual disease which is on the basis of subsequent relapses. The adhesion signaling pathways have been extensively studied in adherent cells as well as in mature hematopoietic cells, but the adhesion structures and signaling in hematopoietic stem and progenitor cells, either normal or malignant, are much less explored. We analyzed the interaction of leukemia cells with fibronectin (FN) using interference reflection microscopy, immunofluorescence, measurement of adherent cell fraction, real-time microimpedance measurement and live cell imaging.