0012722 2020 RIV GB eng J
Folta, A. - Čulen, M. - Ježíšková, I. - Herudková, Z. - Tom, N. - Hlubinková, T. - Janečková, V. - Ďuriníková, A. - Vydra, Jan - Semerád, L. - Dvořáková, D. - Remešová, Hana - Cerovská, Ela - Cetkovský, Petr - et al.
Prognostic significance of mutation profile at diagnosis and mutation persistence during disease remission in adult acute myeloid leukaemia patients.
British journal of haematology. Vol. 186, no. 2 (2019), s. 300-310. ISSN 0007-1048
Grant: Ministerstvo zdravotnictví NV15-25809A
Klíčová slova: acute myeloid leukemia * next-generation sequencing * persistent mutations
Cite Score: 8.100, rok: 2019; SJR: 1.844, rok: 2019; IF: 5.518, rok: 2019
DOI: 10.1111/bjh.15916

Anotace: In this multi-centre study, we analysed the prognostic impact of mutations in 19 genes associated with myeloid malignancies in 258 newly diagnosed acute myeloid leukaemia patients (aged 19–70 years) undergoing intensive therapy. We identified five patient groups with different prognostic risks and different benefits from allogeneic hematopoietic stem cell transplantation (alloHSCT) within the intermediate cytogenetic risk group patients (n = 184). The most adverse prognosis was observed in patients with DNMT3A and FLT3-ITD co-mutation, whose survival could be significantly improved with alloHSCT. In contrast, the most favourable prognosis without any further benefit from alloHSCT was identified in patients with mutations in NPM1 or CEBPA, after exclusion of the unfavourable prognostic groups defined by mutations in DNMT3A, RUNX1 or genes from chromatin/spliceosome group.