Počet záznamů: 1
DNA methylation and hydroxymethylation patterns in acute myeloid leukemia patients with mutations in DNMT3A and IDH1/2 and their combinations
- 1.0012758 2020 RIV NL eng J
Šestáková, Šárka - Krejčík, Zdeněk - Folta, A. - Cerovská, Ela - Šálek, Cyril - Dostálová Merkerová, Michaela - Pecherková, Pavla - Ráčil, Z. - Mayer, J. - Cetkovský, Petr - Remešová, HanaG
DNA methylation and hydroxymethylation patterns in acute myeloid leukemia patients with mutations in DNMT3A and IDH1/2 and their combinations.
Cancer biomarkers. Vol. 25, no. 1 (2019), s. 43-51. ISSN 1574-0153
Grant: Ministerstvo zdravotnictví NV15-25809A
Klíčová slova: AML * DNMT3A and IDH1/2 mutations * GZMB * methylation
Cite Score: 4.800, rok: 2019; SJR: 0.874, rok: 2019; IF: 3.436, rok: 2019
DOI: 10.3233/CBM-182176
Anotace: The aim was to analyze DNA methylation, hydroxymethylation and mRNA expression profiles in AML with mutations in DNMT3A and IDH1/2 (individually and in combinations). Distinct molecular background results in specific DNA hydroxy-/methylation profiles in AML. Site-specific DNA hydroxymethylation changes are much less frequent in AML pathogenesis compared to DNA methylation. Methylation levels of enhancer located upstream GZMB gene might contribute to AML prognostication models.
Počet záznamů: 1