0012945 2021 RIV US eng J
Sovová, Žofie^G - Štikarová, Jana - Kaufmanová, J. - Májek, Pavel - Suttnar, Jiří - Šácha, P. - Malý, M. - Dyr, Jan Evangelista
Impact of posttranslational modifications on atomistic structure of fibrinogen.
PLoS one. Vol. 15, no. 1 (2020), art. no. e0227543. ISSN 1932-6203
Grant: Ministerstvo zdravotnictví IP; Grantová agentura ČR GBP205/12/G118
Klíčová slova: fibrinogen * oxidative stress * post-translational modifications (PTMs)
Cite Score: 5.300, rok: 2020; SJR: 0.990, rok: 2020; IF: 3.240, rok: 2020
DOI: 10.1371/journal.pone.0227543

Anotace: Oxidative stress in humans is related to various pathophysiological processes, which can manifest in numerous diseases including cancer, cardiovascular diseases, and Alzheimer's disease. On the atomistic level, oxidative stress causes posttranslational modifications, thus inducing structural and functional changes into the proteins structure. This study focuses on fibrinogen, a blood plasma protein that is frequently targeted by reagents causing posttranslational modifications in proteins.