0013101 2022 RIV US eng J
Kuželová, Kateřina^G - Obr, Adam - Röselová, Pavla - Grebeňová, Dana - Otevřelová, Petra - Brodská, Barbora - Holoubek, Aleš
Group I p21-activated kinases in leukemia cell adhesion to fibronectin.
Cell adhesion & migration. Vol. 15, no. 1 (2021), s. 18-36. ISSN 1933-6918
Grant: Grantová agentura ČR GA16-16169S
Institucionální podpora: RVO:00023736
Klíčová slova: PAK * acute myeloid leukemia * cell adhesion * ECIS * IRM
Cite Score: 6.400, rok: 2021; SJR: 0.815, rok: 2021; IF: 3.255, rok: 2021
DOI: 10.1101/2020.08.25.266056

Anotace: P21-activated kinases (PAK) regulate many processes associated with cytoskeleton dynamics, including cell adhesion, migration, and apoptosis. PAK function is frequently altered in cancer, and PAK were proposed as therapy targets both in solid tumors and in hematological malignancies. We measured expression of PAK group I members in leukemia cell lines and in primary leukemia cells, both on protein and mRNA levels.