0013103 2021 RIV US eng J
Šálek, Cyril^G - Vydra, Jan - Cerovská, Ela - Šestáková, Šárka - Ransdorfová, Šárka - Válková, Veronika - Cetkovský, Petr - Remešová, Hana
WT1 expression in peripheral blood at diagnosis and during the course of early consolidation treatment correlates with survival in patients with intermediate and poor-risk acute myeloid leukemia.
Clinical lymphoma myeloma & leukemia. Vol. 20, no. 12 (2020) s. e998-e1009. ISSN 2152-2650
Grant: Ministerstvo zdravotnictví IP
Klíčová slova: acute myeloid leukemia * minimal residual disease * molecular markers * prognostic factors * WT-1
Cite Score: 3.300, rok: 2020; SJR: 0.940, rok: 2020; IF: 3.231, rok: 2020
DOI: 10.1016/j.clml.2020.07.014

Anotace: We aimed to evaluate the prognostic significance of WT1 gene expression at early stages of intensive treatment. Dynamics of WT1 expression during the course of chemotherapy was tested in 106 cases of intermediate and high-risk acute myeloid leukemia in peripheral blood. High WT1 expression after 2 cycles of chemotherapy was a significant prognostic factor for overall and event-free survival in the whole cohort, as well as in patients treated without allogeneic stem cell transplantation.