0013204 2022 RIV GB eng J
Táborská, J. - Riedelová, Z. - Brynda, E. - Májek, Pavel - Riedel, T.
Endothelialization of an ePTFE vessel prosthesis modified with an antithrombogenic fibrin/heparin coating enriched with bound growth factors.
RSC advances. Vol. 11, no. 11 (2021), s. 5903-5913. ISSN 2046-2069
Institucionální podpora: RVO:00023736
Klíčová slova: prosthetics * endothelial cells * antithrombogenic fibrin/heparin * expanded polytetrafluorethylene (ePTFE) vessel prosthesis
Cite Score: 5.900, rok: 2021; SJR: 0.667, rok: 2021; IF: 4.036, rok: 2021
DOI: 10.1039/d1ra00053e

Anotace: Early and late thrombosis remain the most frequent reasons for the failure of synthetic cardiovascular grafts. Long-term hemocompatibility of implanted synthetic grafts can be achieved if a natural living endothelium is formed over its blood-contacting surface. Here we present a modification of a standard expanded polytetrafluorethylene (ePTFE) vessel prosthesis by a controlled preparation of a fibrin mesh enriched with covalently bound heparin and noncovalently bound vascular endothelial growth factor (VEGF) and fibroblast growth factor (FGF).