0013234 2022 RIV CH eng J
Sovová, Žofie^G - Suttnar, Jiří - Dyr, Jan Evangelista
Molecular dynamic simulations suggest that metabolite-induced post-translational modifications alter the behavior of the fibrinogen coiled-coil domain.
Metabolites. Vol. 11, no. [nečíslováno] (2021), art. no. 307. ISSN 2218-1989
Grant: Grantová agentura ČR GA19-02739S; Ministerstvo zdravotnictví NV18-08-00149
Institucionální podpora: RVO:00023736
Klíčová slova: fibrinogen * post-translational modifications (PTMs) * molecular dynamic simulation * oxidation * citrullination * coiled‐coil
Cite Score: 4.700, rok: 2021; SJR: 0.956, rok: 2021; IF: 5.581, rok: 2021
DOI: 10.3390/metabo11050307

Anotace: Fibrinogen is an abundant blood plasma protein that, inter alia, participates in blood coagulation. It polymerizes to form a fibrin clot that is among the major components of the thrombus. Fibrinogen reactions with various reactive metabolites may induce post‐translational modifications (PTMs) into the protein structure that affect the architecture and properties of fibrin clots. We reviewed the previous literature to find the positions of PTMs of fibrinogen.