0013294 2022 RIV CZ eng J
Smetana, Karel^G - Mikulenková, Dana - Klamová, Hana
The morphology of cell differentiation, terminal differentiation and ageing seems to reflect the same process: a short note.
Folia biologica. Roč. 67, č. 2 (2021), s. 70-75. ISSN 0015-5500
Institucionální podpora: RVO:00023736
Klíčová slova: granulocytic precursors * chronic myeloid leukemia * heterochromatin
Cite Score: 1.500, rok: 2021; SJR: 0.288, rok: 2021; IF: 1.167, rok: 2021

Anotace: Based on simple microscopic cell morphology in blood and bone marrow smear preparations, it seems to be likely that the cell differentiation and terminal differentiation in human blood cells, and particularly in erythroid or granulocytic lineages, simultaneously reflect ageing of the lineage progenitors and terminal differentiation steps. The terminal differentiation stages of both these lineages actually appear as senescent cells. Abnormal ageing of progenitor cells may represent one of the ,,dysplastic,, phenomena of the premature terminal differentiation state. Such state is characterized by heterochromatin condensation and nucleolar morphology similar to that in fully differentiated terminal cells of granulocytic or erythroid lineages.