0013361 2023 RIV DE eng J
Riedel, T. - de los Santos Pereira, A. - Táborská, J. - Riedelová, Z. - Pop-Georgievski, O. - Májek, Pavel - Pečánková, Klára - et al.
Complement activation dramatically accelerates blood plasma fouling on antifouling poly(2-hydroxyethyl methacrylate) brush surfaces.
Macromolecular bioscience. Vol. 22, no. 3 (2022), art. no. e2100460. ISSN 1616-5187
Grant: Grantová agentura ČR GA20-10845S
Institucionální podpora: RVO:00023736
Klíčová slova: blood * poly(2-hydroxyethyl methacrylate) * blood plasma
Cite Score: 8.400, rok: 2022; SJR: 0.855, rok: 2022; IF: 4.6, rok: 2022
DOI: 10.1002/mabi.202100460

Anotace: Non-specific protein adsorption (fouling) triggers a number of deleterious events in the application of biomaterials. Antifouling polymer brushes successfully suppress fouling, however for some coatings an extremely high variability of fouling for different donors remains unexplained. The authors report that in the case of poly(2-hydroxyethyl methacrylate) (poly(HEMA)) this variability is due to the complement system activation that causes massive acceleration in the fouling kinetics of blood plasma. Using plasma from various donors, the fouling kinetics on poly(HEMA) is analyzed and correlated with proteins identified in the deposits on the surface and with the biochemical compositions of the plasma