0013438 2023 RIV DE eng J
Riedelová, Z. - de los Santos Pereira, A. - Svoboda, J. - Pop-Georgievski, O. - Májek, Pavel - Pečánková, Klára - Dyčka, F. - Rodriguez Emmenegger, C. - Riedel, T.
The relation between protein adsorption and hemocompatibility of antifouling polymer brushes.
Macromolecular bioscience. Vol. 22, no. 11 (2022), art. no. e2200247. ISSN 1616-5187
Grant: Grantová agentura ČR GA20-10845S
Institucionální podpora: RVO:00023736
Klíčová slova: MS identification * antifouling surfaces * hemocompatibility
Cite Score: 8.400, rok: 2022; SJR: 0.855, rok: 2022; IF: 4.6, rok: 2022
DOI: 10.1002/mabi.202200247

Anotace: Whenever an artificial surface comes into contact with blood, proteins are rapidly adsorbed onto its surface. This phenomenon, termed fouling, is then followed by a series of undesired reactions involving activation of complement or the coagulation cascade and adhesion of leukocytes and platelets leading to thrombus formation. Thus, considerable efforts are directed towards the preparation of fouling-resistant surfaces with the best possible hemocompatibility. Herein, a comprehensive hemocompatibility study after heparinized blood contact with seven polymer brushes prepared by surface-initiated atom transfer radical polymerization is reported.