Počet záznamů: 1
Good manufacturing practice-grade generation of CD19 and CD123-specific CAR-T cells using piggyBac transposon and allogeneic feeder cells in patients diagnosed with B-cell non-Hodgkin lymphoma and acute myeloid leukemia
- 1.0013709 2025 RIV CH eng J
Mucha, Martin - Štach, Martin - Kaštánková, Iva - Rychlá, Jana - Vydra, Jan - Lesný, Petr - Otáhal, PavelG
Good manufacturing practice-grade generation of CD19 and CD123-specific CAR-T cells using piggyBac transposon and allogeneic feeder cells in patients diagnosed with B-cell non-Hodgkin lymphoma and acute myeloid leukemia.
Frontiers in immunology. Vol. 15, no. August (2024), art. no. 1415328. ISSN 1664-3224
Grant: Ministerstvo zdravotnictví NU22-05-00374
Institucionální podpora: RVO:00023736
Klíčová slova: CAR-T cells * piggyBac transposon * leukemia
Cite Score: 10.800, rok: 2024; SJR: 1.941, rok: 2024; IF: 5.9, rok: 2024
DOI: 10.3389/fimmu.2024.1415328
Anotace: The non-viral production of CAR-T cells through electroporation of transposon DNA plasmids is an alternative approach to lentiviral/retroviral methods. This method is particularly suitable for early-phase clinical trials involving novel types of CAR-T cells. The primary disadvantage of non-viral methods is the lower production efficiency compared to viral-based methods, which becomes a limiting factor for CAR-T production, especially in chemotherapy-pretreated lymphopenic patients.
Počet záznamů: 1