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  1. 1.paktamycín

    Subject h.paktamycín
    Subject h.Pactamycin
    Scope note in EnglishAntibiotic produced by Streptomyces pactum used as an antineoplastic agent. It is also used as a tool in biochemistry because it inhibits certain steps in protein synthesis.
    Pharmacology effect antibiotiká protinádorové
    inhibítory proteosyntézy
    Pharmacology effect Antibiotics, Antineoplastic
    Protein Synthesis Inhibitors
    subject heading

    subject heading

  2. 2.erytromycín estolát

    Subject h.erytromycín estolát
    Subject h.Erythromycin Estolate
    English X referencesErythromycin Propionate Dodecyl Sulfate
    Erythromycin Propionate Lauryl Sulfate
    Scope note in EnglishA macrolide antibiotic, produced by Streptomyces erythreus. It is the lauryl sulfate salt of the propionic ester of erythromycin. This erythromycin salt acts primarily as a bacteriostatic agent. In sensitive organisms, it inhibits protein synthesis by binding to 50S ribosomal subunits. This binding process inhibits peptidyl transferase activity and interferes with translocation of amino acids during translation and assembly of proteins.
    Pharmacology effect antibiotiká
    inhibítory enzýmov
    látky gastrointestinálne
    inhibítory proteosyntézy
    Pharmacology effect Anti-Bacterial Agents
    Enzyme Inhibitors
    Gastrointestinal Agents
    Protein Synthesis Inhibitors
    subject heading

    subject heading

  3. 3.daktinomycín

    Subject h.daktinomycín
    Subject h.Dactinomycin
    Entry termsaktinomycín
    aktinomycín D
    meraktinomycín
    English X referencesActinomycin
    Actinomycin D
    Meractinomycin
    Scope note in EnglishA compound composed of a two CYCLIC PEPTIDES attached to a phenoxazine that is derived from STREPTOMYCES parvullus. It binds to DNA and inhibits RNA synthesis (transcription), with chain elongation more sensitive than initiation, termination, or release. As a result of impaired mRNA production, protein synthesis also declines after dactinomycin therapy. (From AMA Drug Evaluations Annual, 1993, p2015)
    Pharmacology effect antibiotiká
    antibiotiká protinádorové
    inhibítory syntézy nukleových kyselín
    inhibítory proteosyntézy
    Pharmacology effect Anti-Bacterial Agents
    Antibiotics, Antineoplastic
    Nucleic Acid Synthesis Inhibitors
    Protein Synthesis Inhibitors
    Links (2) - BOOKS
    subject heading

    subject heading

  4. 4.shiga toxíny

    Subject h.shiga toxíny
    Subject h.Shiga Toxins
    Entry termsvero toxín
    vero toxíny
    vero-toxín
    vero-toxíny
    šiga-toxíny
    šiga toxíny
    English X referencesVero Toxin
    Vero Toxins
    Scope note in EnglishA class of toxins that inhibit protein synthesis by blocking the interaction of ribosomal RNA; (RNA, RIBOSOMAL) with PEPTIDE ELONGATION FACTORS. They include SHIGA TOXIN which is produced by SHIGELLA DYSENTERIAE and a variety of shiga-like toxins that are produced by pathologic strains of ESCHERICHIA COLI such as ESCHERICHIA COLI O157.
    Pharmacology effect inhibítory proteosyntézy
    Pharmacology effect Protein Synthesis Inhibitors
    See also reference (FX) in Slovak dyzentéria
    See also reference (FX) in English Dysentery
    Links (1) - ARTICLES
    (1) - MeSH descriptor
    subject heading

    subject heading

  5. 5.chlórtetracyklín

    Subject h.chlórtetracyklín
    Subject h.Chlortetracycline
    Scope note in EnglishA TETRACYCLINE with a 7-chloro substitution.
    Pharmacology effect antibiotiká
    antiprotozoiká
    inhibítory proteosyntézy
    Pharmacology effect Anti-Bacterial Agents
    Antiprotozoal Agents
    Protein Synthesis Inhibitors
    Links (2) - ARTICLES
    (1) - BOOKS
    subject heading

    subject heading

  6. 6.tosyllyzínchlórmetylketón

    Subject h.tosyllyzínchlórmetylketón
    Subject h.Tosyllysine Chloromethyl Ketone
    Entry termschlórtosylamidoaminoheptanón
    TLCK
    tosyllyzylchlórmetán
    English X referencesChlorotosylamidoaminoheptanone
    TLCK
    Tosyllysyl Chloromethane
    Scope note in EnglishAn inhibitor of SERINE ENDOPEPTIDASES. Acts as an alkylating agent and is known to interfere with the translation process.
    Pharmacology effect činidlá alkylačné
    inhibítory proteosyntézy
    inhibítory serínových proteináz
    Pharmacology effect Alkylating Agents
    Protein Synthesis Inhibitors
    Serine Proteinase Inhibitors
    subject heading

    subject heading

  7. 7.brefeldín A

    Subject h.brefeldín A
    Subject h.Brefeldin A
    Entry termsaskotoxín
    dekumbín
    kyaneín
    Scope note in EnglishA fungal metabolite which is a macrocyclic lactone exhibiting a wide range of antibiotic activity.
    Pharmacology effect antibiotiká
    antimykotiká
    antivirotiká
    inhibítory proteosyntézy
    Pharmacology effect Anti-Bacterial Agents
    Antifungal Agents
    Antiviral Agents
    Protein Synthesis Inhibitors
    Links (3) - ARTICLES
    subject heading

    subject heading

  8. 8.elongácia peptidového reťazca, translačná

    Subject h.elongácia peptidového reťazca, translačná
    Subject h.Peptide Chain Elongation, Translational
    Entry termspredĺženie peptidového reťazca, translačné
    Scope note in EnglishA process of GENETIC TRANSLATION, when an amino acid is transferred from its cognate TRANSFER RNA to the lengthening chain of PEPTIDES.
    See also reference (FX) in Slovak faktory elongačné peptidové
    peptidyltransferázy
    inhibítory proteosyntézy
    See also reference (FX) in English Peptide Elongation Factors
    Peptidyl Transferases
    Protein Synthesis Inhibitors
    Links (3) - MeSH descriptor
    subject heading

    subject heading

  9. 9.kyselina fusidová

    Subject h.kyselina fusidová
    Subject h.Fusidic Acid
    Entry termskyselina fuzidová
    fusidát sodný
    fucidín
    Scope note in EnglishAn antibiotic isolated from the fermentation broth of Fusidium coccineum. (From Merck Index, 11th ed). It acts by inhibiting translocation during protein synthesis.
    Pharmacology effect antibiotiká
    inhibítory proteosyntézy
    Pharmacology effect Anti-Bacterial Agents
    Protein Synthesis Inhibitors
    Links (7) - ARTICLES
    subject heading

    subject heading

  10. 10.cykloheximid

    Subject h.cykloheximid
    Subject h.Cycloheximide
    Scope note in EnglishAntibiotic substance isolated from streptomycin-producing strains of Streptomyces griseus. It acts by inhibiting elongation during protein synthesis.
    Pharmacology effect antimykotiká
    inhibítory proteosyntézy
    Pharmacology effect Antifungal Agents
    Protein Synthesis Inhibitors
    Links (1) - ARTICLES
    subject heading

    subject heading


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