variácia počtu kópií DNA zmena počtu kópií DNA zmeny počtu kópií DNA polymorfizmus počtu kópií DNA polymorfizmy počtu kópií DNA odchýlka počtu kópií DNA odchýlky počtu kópií DNA rozdiely v počte kópií DNA variabilta v počte kópií segmentov DNA
English X references
Copy Number Polymorphism DNA Copy Number Variant
Scope note in English
Stretches of genomic DNA that exist in different multiples between individuals. Many copy number variations have been associated with susceptibility or resistance to disease.
A selective increase in the number of copies of a gene coding for a specific protein without a proportional increase in other genes. It occurs naturally via the excision of a copy of the repeating sequence from the chromosome and its extrachromosomal replication in a plasmid, or via the production of an RNA transcript of the entire repeating sequence of ribosomal RNA followed by the reverse transcription of the molecule to produce an additional copy of the original DNA sequence. Laboratory techniques have been introduced for inducing disproportional replication by unequal crossing over, uptake of DNA from lysed cells, or generation of extrachromosomal sequences from rolling circle replication.
See also reference (FX) in Slovak
dávka génová
See also reference (FX) in English
Gene Dosage
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