Number of the records: 1
zidovudín
SYS d015215 LBL 00000cx--j22000003--45-- 005 20240119201240.3 100 $a 19920509csloy0103----ba0 152 $b mesh 250 $a zidovudín $x AA $x AD $x AE $x AG $x AI $x AN $x BL $x CF $x CH $x CL $x CS $x EC $x HI $x IM $x IP $x ME $x PD $x PK $x PO $x RE $x SD $x ST $x TO $x TU $x UR $8 slo 300 1-
$a 89 $8 eng 300 1-
$a Thymidine/analogs & derivatives (1975-1988) $8 eng 330 1-
$a A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by an azido group. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. The compound is a potent inhibitor of HIV replication, acting as a chain-terminator of viral DNA during reverse transcription. It improves immunologic function, partially reverses the HIV-induced neurological dysfunction, and improves certain other clinical abnormalities associated with AIDS. Its principal toxic effect is dose-dependent suppression of bone marrow, resulting in anemia and leukopenia. $8 eng 450 $a AZT (Antiviral) $5 e $8 eng 450 $a Azidothymidine $5 e $8 eng 450 $a azidotymidín $5 e $8 slo 450 $a AZT (antivírusový) $5 e $8 slo 550 $3 sllk_un_auth*d019380 $Y Anti-HIV Agents $5 P $a látky proti HIV 550 $3 sllk_un_auth*d000963 $Y Antimetabolites $5 P $a antimetabolity 550 $3 sllk_un_auth*d018894 $Y Reverse Transcriptase Inhibitors $5 P $a inhibítory reverznej transkriptázy 686 $a D03.383.742.680.705.950 686 $a D13.570.230.500.950 686 $a D13.570.230.855.950 686 $a D13.570.685.705.950 750 $a Zidovudine $8 eng 801 -0
$a US $b DNLM $c 19920509 801 -2
$a SK $b BA006 $c 20010828 980 $x M
Number of the records: 1