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zosilňovač zeste homológ 2 proteínu

  1. Subject h.zosilňovač zeste homológ 2 proteínu
    Subject h.Enhancer of Zeste Homolog 2 Protein
    Entry termsenhancer zeste homológu 2
    histón-lyzín N-metyltransferáza EZH2
    lyzín N-metyltransferáza-6
    Scope note in EnglishA histone-lysine N-methyltransferase and catalytic subunit of Polycomb Repressive Complex 2. It methylates LYSINE 9 (H3K9me) and LYSINE 27 (H3K27me) of HISTONE H3, leading to transcriptional repression of the affected target gene. EZH2 also methylates non-histone proteins such as GATA4 TRANSCRIPTION FACTOR and the nuclear receptor RORA. It regulates CIRCADIAN CLOCKS via histone methylation of circadian protein gene PROMOTER REGIONS, and its repressive activity is also important for the identity and differentiation of EMBRYONIC STEM CELLS.
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